Assay Detail
Functional
CHEMBL800281
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In vitro inhibition of lipid autoxidation (TBARS formation) of rat brain homogenate
20
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
2,3-Dihydro-1-benzofuran-5-ols as analogues of alpha-tocopherol that inhibit in vitro and ex vivo lipid autoxidation and protect mice against central nervous system trauma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.78 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140751 | — | — | 1 | 6.52 |
| CHEMBL140480 | — | — | 1 | 6.40 |
| CHEMBL140752 | — | — | 1 | 6.40 |
| CHEMBL142037 | — | — | 3 | 6.40 |
| CHEMBL140386 | — | — | 1 | 6.30 |
| CHEMBL356883 | — | — | 1 | 6.16 |
| CHEMBL540355 | — | — | 1 | 6.16 |
| CHEMBL443544 | — | — | 1 | 5.92 |
| CHEMBL143320 | — | — | 1 | 5.85 |
| CHEMBL99134 | — | — | 1 | 5.70 |
| CHEMBL140227 | — | — | 1 | 5.58 |
| CHEMBL143229 | — | — | 1 | 5.48 |
| CHEMBL143404 | — | — | 1 | 5.44 |
| CHEMBL275786 | — | — | 1 | 5.41 |
| CHEMBL143381 | — | — | 1 | 4.92 |
| CHEMBL47 | ALPHA-TOCOPHEROL | — | 1 | 4.85 |
| CHEMBL143683 | — | — | 1 | 4.72 |
| CHEMBL141290 | — | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140751 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL140752 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL142037 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL142037 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL140480 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL142037 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL140386 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL356883 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL540355 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL443544 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL143320 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL99134 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL140227 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL143229 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL143404 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL275786 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL143381 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL47 | ALPHA-TOCOPHEROL | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL143683 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL141290 | — | IC50 | = | 27000.0 | nM | 4.57 |