Assay Detail
Functional
CHEMBL800350
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibition of [3H]dopamine uptake (DAUI) in rat synaptosomes
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity relationships at monoamine transporters for a series of N-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes: comparative molecular field analysis, synthesis, and pharmacological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.50 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3085020 | — | — | 1 | 8.30 |
| CHEMBL115253 | — | — | 1 | 8.19 |
| CHEMBL324518 | — | — | 1 | 8.09 |
| CHEMBL317757 | DIFLUOROBENZTROPINE | — | 1 | 7.86 |
| CHEMBL112528 | — | — | 1 | 7.85 |
| CHEMBL327055 | — | — | 1 | 7.73 |
| CHEMBL325826 | — | — | 1 | 7.65 |
| CHEMBL3084884 | — | — | 1 | 7.63 |
| CHEMBL3085021 | — | — | 1 | 7.58 |
| CHEMBL2308105 | — | — | 1 | 7.41 |
| CHEMBL326706 | — | — | 1 | 7.31 |
| CHEMBL111928 | — | — | 1 | 6.64 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.63 |
| CHEMBL115710 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3085020 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL115253 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL324518 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL317757 | DIFLUOROBENZTROPINE | IC50 | = | 13.8 | nM | 7.86 |
| CHEMBL112528 | — | IC50 | = | 14.2 | nM | 7.85 |
| CHEMBL327055 | — | IC50 | = | 18.7 | nM | 7.73 |
| CHEMBL325826 | — | IC50 | = | 22.3 | nM | 7.65 |
| CHEMBL3084884 | — | IC50 | = | 23.4 | nM | 7.63 |
| CHEMBL3085021 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2308105 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL326706 | — | IC50 | = | 48.9 | nM | 7.31 |
| CHEMBL111928 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL370805 | COCAINE | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL115710 | — | IC50 | = | 659.0 | nM | 6.18 |