Assay Detail
Functional
CHEMBL800355
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Concentration that produces 50% of the maximal response to compound in rat thoracic aorta strips in the presence of PBZ and CIR
5
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Thoracic aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.67 | 4.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56999 | — | — | 1 | 4.83 |
| CHEMBL54959 | — | — | 2 | 4.79 |
| CHEMBL2115064 | — | — | 1 | 4.59 |
| CHEMBL59034 | — | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56999 | — | EC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL54959 | — | EC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL54959 | — | EC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL2115064 | — | EC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL59034 | — | EC50 | = | 43000.0 | nM | 4.37 |