Assay Detail
Functional
CHEMBL800360
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Concentration that produces 50% of the maximal response to compound in rat thoracic aorta strips in the presence of nifedipine
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Thoracic aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.33 | 4.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2115064 | — | — | 1 | 4.54 |
| CHEMBL55311 | — | — | 1 | 4.31 |
| CHEMBL54959 | — | — | 1 | 4.28 |
| CHEMBL56999 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2115064 | — | EC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL55311 | — | EC50 | = | 48500.0 | nM | 4.31 |
| CHEMBL54959 | — | EC50 | = | 52100.0 | nM | 4.28 |
| CHEMBL56999 | — | EC50 | = | 67000.0 | nM | 4.17 |