Assay Detail
Functional
CHEMBL800365
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Concentration that produces 50% of the maximal response to compound without phenoxybenzamine pretreatment on rat thoracic aorta strips
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Thoracic aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 4.56 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56898 | — | — | 1 | 5.52 |
| CHEMBL300605 | — | — | 1 | 5.00 |
| CHEMBL56999 | — | — | 1 | 4.54 |
| CHEMBL2115064 | — | — | 1 | 4.51 |
| CHEMBL55311 | — | — | 1 | 4.39 |
| CHEMBL55074 | — | — | 1 | 4.33 |
| CHEMBL59034 | — | — | 1 | 4.32 |
| CHEMBL301859 | — | — | 1 | 4.24 |
| CHEMBL54959 | — | — | 1 | 4.16 |
| CHEMBL301662 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56898 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL300605 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL56999 | — | EC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL2115064 | — | EC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL55311 | — | EC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL55074 | — | EC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL59034 | — | EC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL301859 | — | EC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL54959 | — | EC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL301662 | — | EC50 | = | 116000.0 | nM | - |