Assay Detail
Functional
CHEMBL800366
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Inhibitory activity against rat thoracic aorta(induced by 30 nM of U-46619)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Thoracic aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and in vitro activity of stereoisomers of a novel thromboxane receptor antagonist, (+-)-(5Z)-7-[3-endo-[(phenylsulfonyl)amino]bicyclo [2.2.1]hept-2-exo-yl]heptenoic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.49 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1744350 | — | — | 1 | 8.85 |
| CHEMBL2448578 | — | — | 1 | 7.84 |
| CHEMBL8101 | — | — | 1 | 7.77 |
| CHEMBL266225 | — | — | 1 | 7.43 |
| CHEMBL266243 | ONO-3708 | — | 1 | 7.28 |
| CHEMBL8273 | SULOTROBAN | 2.0 | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1744350 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2448578 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL8101 | — | IC50 | = | 16.9 | nM | 7.77 |
| CHEMBL266225 | — | IC50 | = | 37.2 | nM | 7.43 |
| CHEMBL266243 | ONO-3708 | IC50 | = | 52.6 | nM | 7.28 |
| CHEMBL8273 | SULOTROBAN | IC50 | = | 1800.0 | nM | 5.75 |