Assay Detail
Functional
CHEMBL800379
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Evaluated for the phosphatidyl inositol turnover at Muscarinic acetylcholine receptor M1 in rat cortex
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Affinity and selectivity of the optical isomers of 3-quinuclidinyl benzilate and related muscarinic antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.20 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2115342 | — | — | 1 | 9.10 |
| CHEMBL549577 | — | — | 1 | 9.05 |
| CHEMBL9967 | PIRENZEPINE | 2.0 | 1 | 8.09 |
| CHEMBL558910 | — | — | 1 | 8.08 |
| CHEMBL1788199 | — | — | 1 | 7.81 |
| CHEMBL2114395 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2115342 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL549577 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL9967 | PIRENZEPINE | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL558910 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL1788199 | — | Ki | = | 15.4 | nM | 7.81 |
| CHEMBL2114395 | — | Ki | = | 87.5 | nM | 7.06 |