Assay Detail
Functional
CHEMBL800391
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for antagonism of clonidine in the field-stimulated rat vas deferens.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
N-(1,3,4,6,7,12b-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin -2-yl)-N- methyl-2-hydroxyethane-sulfonamide: a potent and selective alpha 2-adrenoceptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 8.23 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48603 | — | — | 1 | 9.10 |
| CHEMBL48558 | — | — | 1 | 8.77 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 7.65 |
| CHEMBL299595 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48603 | — | Kd | = | 0.7943 | nM | 9.10 |
| CHEMBL48558 | — | Kd | = | 1.698 | nM | 8.77 |
| CHEMBL15245 | YOHIMBINE | Kd | = | 22.39 | nM | 7.65 |
| CHEMBL299595 | — | Kd | = | 39.81 | nM | 7.40 |