Assay Detail
Functional
CHEMBL800392
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for antagonism of methoxamine in the field-stimulated rat vas deferens.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
N-(1,3,4,6,7,12b-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin -2-yl)-N- methyl-2-hydroxyethane-sulfonamide: a potent and selective alpha 2-adrenoceptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.64 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48603 | — | — | 1 | 7.46 |
| CHEMBL48558 | — | — | 1 | 6.99 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 6.52 |
| CHEMBL299595 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48603 | — | Kd | = | 34.67 | nM | 7.46 |
| CHEMBL48558 | — | Kd | = | 102.33 | nM | 6.99 |
| CHEMBL15245 | YOHIMBINE | Kd | = | 302.0 | nM | 6.52 |
| CHEMBL299595 | — | Kd | = | 2511.89 | nM | 5.60 |