Assay Detail
Binding
CHEMBL800546
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Transcriptional activation of CV-1 cells expressing murine Retinoid X receptor RXR alpha
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Heteroarotinoids inhibit head and neck cancer cell lines in vitro and in vivo through both RAR and RXR retinoic acid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.81 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139536 | — | — | 1 | 7.08 |
| CHEMBL341704 | — | — | 1 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139536 | — | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL341704 | — | EC50 | = | 294.0 | nM | 6.53 |