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Compound Detail

CHEMBL341704

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CC1(C)CCOc2ccc(C(=O)Oc3ccc(/C=N/N=C(/N)S)cc3)cc21

Basic Information

ChEMBL ID CHEMBL341704
Phase Preclinical
Structure Type MOL
InChI Key SMLQDCCTDXVYIJ-WSDLNYQXSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

383.5
MW (Da)
3.54
ALogP
5
HBA
2
HBD
86.3
PSA (Ų)
0.21
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H21N3O3S
MW 383.47
Aromatic Rings 2
Heavy Atoms 27
NP-Likeness -0.42

Activity Summary

EC50 3 meas. best 7.38

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Retinoic acid receptor RXR-gamma
CHEMBL4402
EC50 7.38 7.38 42.0 1
Retinoic acid receptor RXR-alpha
CHEMBL3084
EC50 6.53 6.53 294.0 1
Retinoic acid receptor RXR-beta
CHEMBL4047
EC50 5.72 5.72 1897.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
10543887 10.1021/jm990292i SCC-2 1
10543887 10.1021/jm990292i SCC-38 1
10543887 10.1021/jm990292i Retinoic acid receptor alpha 1
10543887 10.1021/jm990292i Retinoic acid receptor beta 1
10543887 10.1021/jm990292i Retinoic acid receptor gamma 1
10543887 10.1021/jm990292i Retinoic acid receptor RXR-alpha 1
10543887 10.1021/jm990292i Retinoic acid receptor RXR-beta 1
10543887 10.1021/jm990292i Retinoic acid receptor RXR-gamma 1

Data from ChEMBL 36 via Core Engine