Assay Detail
Functional
CHEMBL800559
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Compound was tested for antagonist activity in rat isolated uterus assay; pA2 is the negative logarithm of the concentration of antagonist that reduces the response to an ED50 dose of angiotensin II to the response to half the ED50 dose
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Uterus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activities of analogues of angiotensins II and III containing O-methyltyrosine and D-tryptophan.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 12 | 7.58 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404594 | — | — | 1 | 8.70 |
| CHEMBL2371021 | — | — | 1 | 8.10 |
| CHEMBL2371461 | — | — | 1 | 7.70 |
| CHEMBL2371453 | — | — | 1 | 7.20 |
| CHEMBL2371455 | — | — | 1 | 7.10 |
| CHEMBL2371452 | — | — | 1 | 6.70 |
| CHEMBL2371463 | — | — | 1 | - |
| CHEMBL2371449 | — | — | 1 | - |
| CHEMBL2371451 | — | — | 1 | - |
| CHEMBL2371454 | — | — | 1 | - |
| CHEMBL2371458 | — | — | 1 | - |
| CHEMBL2371460 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404594 | — | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL2371021 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL2371461 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL2371453 | — | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL2371455 | — | Kd | = | 79.43 | nM | 7.10 |
| CHEMBL2371452 | — | Kd | = | 199.53 | nM | 6.70 |
| CHEMBL2371463 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL2371449 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL2371451 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL2371454 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL2371458 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL2371460 | — | Kd | > | 1000.0 | nM | - |