Assay Detail
Binding
CHEMBL800581
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Inhibitory activity against HIV-1 reverse transcriptase
16
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
All-atom models for the non-nucleoside binding site of HIV-1 reverse transcriptase complexed with inhibitors: a 3D QSAR approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.47 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42906 | — | — | 1 | 6.72 |
| CHEMBL295978 | — | — | 1 | 6.22 |
| CHEMBL42132 | — | — | 1 | 5.91 |
| CHEMBL297982 | — | — | 1 | 5.79 |
| CHEMBL43308 | — | — | 1 | 5.69 |
| CHEMBL288062 | — | — | 1 | 5.62 |
| CHEMBL43283 | — | — | 1 | 5.57 |
| CHEMBL431931 | — | — | 1 | 5.41 |
| CHEMBL43324 | — | — | 1 | 5.41 |
| CHEMBL44392 | — | — | 1 | 5.25 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.19 |
| CHEMBL37628 | — | — | 1 | 4.99 |
| CHEMBL297115 | — | — | 2 | 4.95 |
| CHEMBL290204 | — | — | 1 | 4.94 |
| CHEMBL295930 | — | — | 1 | 4.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42906 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL295978 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL42132 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL297982 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL43308 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL288062 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL43283 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL431931 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL43324 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL44392 | — | IC50 | = | 5630.0 | nM | 5.25 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 6440.0 | nM | 5.19 |
| CHEMBL37628 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL297115 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL297115 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL290204 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL295930 | — | IC50 | = | 12200.0 | nM | 4.91 |