Compound Detail
CHEMBL290204
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Basic Information
| ChEMBL ID | CHEMBL290204 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VJGRDTMGDGDUAA-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
290.3
MW (Da)
2.65
ALogP
6
HBA
0
HBD
59.7
PSA (Ų)
0.69
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.11
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase CHEMBL247 | IC50 | 5.11 | 4.9967 | 7820.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase | IC50 | = | 7820.0 | nM | 5.11 | Ability to inhibit HIV-1 IIIB reverse transcriptase catalyzed incorporation of t... | - |
| Human immunodeficiency virus type 1 reverse transcriptase | IC50 | = | 11500.0 | nM | 4.94 | Inhibitory activity against HIV-1 reverse transcriptase | 8648604 |
| Human immunodeficiency virus type 1 reverse transcriptase | IC50 | = | 11500.0 | nM | 4.94 | Ability to inhibit HIV-1 IIIB reverse transcriptase catalyzed incorporation of t... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(00)80468-0 | Human immunodeficiency virus type 1 reverse transcriptase | 2 |
| 8648604 | 10.1021/jm9508088 | Human immunodeficiency virus type 1 reverse transcriptase | 1 |
Data from ChEMBL 36 via Core Engine