Assay Detail
Binding
CHEMBL800619
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Evaluated for the 50% inhibition of S-Adenosyl-homocysteine (AdoHcy) hydrolase L929 lysate from murine L-929 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | L929 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 11. Molecular dissections of neplanocin A as potential inhibitors of S-adenosylhomocysteine hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.93 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8771 | NEOPLANOCIN A | — | 1 | 7.30 |
| CHEMBL296880 | — | — | 1 | 4.21 |
| CHEMBL49908 | — | — | 1 | 4.19 |
| CHEMBL416457 | — | — | 1 | 4.00 |
| CHEMBL49737 | — | — | 1 | - |
| CHEMBL50600 | — | — | 1 | - |
| CHEMBL49511 | — | — | 1 | - |
| CHEMBL49917 | — | — | 1 | - |
| CHEMBL415930 | — | — | 1 | - |
| CHEMBL45537 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8771 | NEOPLANOCIN A | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL296880 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL49908 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL416457 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL49737 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL50600 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL49511 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL49917 | — | IC50 | = | 230000.0 | nM | - |
| CHEMBL415930 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL45537 | — | IC50 | = | 145000.0 | nM | - |