Assay Detail
Binding
CHEMBL800760
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Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR gamma
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Conformationally defined retinoic acid analogues. 4. Potential new agents for acute promyelocytic and juvenile myelomonocytic leukemias.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.80 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 8.22 |
| CHEMBL44582 | — | — | 1 | 7.38 |
| CHEMBL296193 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL44582 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL296193 | — | EC50 | > | 2000.0 | nM | - |