Assay Detail
Binding
CHEMBL800762
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Binding affinity against retinoic Acid X gamma receptors co-transfected into CV-1 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of high specific activity [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.96 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 6.85 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 5.96 |
| CHEMBL32505 | — | — | 1 | 5.82 |
| CHEMBL284937 | — | — | 1 | 5.58 |
| CHEMBL424636 | — | — | 1 | 5.57 |
| CHEMBL275311 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL705 | ALITRETINOIN | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL38 | TRETINOIN | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL32505 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL284937 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL424636 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL275311 | — | EC50 | > | 10000.0 | nM | - |