Assay Detail
Binding
CHEMBL800768
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Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]9-cis-RA as a radioligand in baculovirus expressed receptor
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of highly potent RXR-specific retinoids: The use of a cyclopropyl group as a double bond isostere
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 7.60 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69091 | — | — | 2 | 8.74 |
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 7.80 |
| CHEMBL308883 | — | — | 1 | 7.38 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 6.46 |
| CHEMBL2111535 | — | — | 1 | - |
| CHEMBL2111534 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69091 | — | Kd | = | 1.8 | nM | 8.74 |
| CHEMBL705 | ALITRETINOIN | Kd | = | 16.0 | nM | 7.80 |
| CHEMBL308883 | — | Kd | = | 42.0 | nM | 7.38 |
| CHEMBL38 | TRETINOIN | Kd | = | 350.0 | nM | 6.46 |
| CHEMBL69091 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL2111535 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL2111534 | — | Kd | > | 1000.0 | nM | - |