Assay Detail
Functional
CHEMBL800789
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Ability to inhibit [Fe2+] induced lipid peroxidation (LPO) in rat brain microsomes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Microsomes |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel dual inhibitors of calpain and lipid peroxidation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.90 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3706732 | — | — | 1 | 7.16 |
| CHEMBL123621 | — | — | 1 | 5.77 |
| CHEMBL333995 | — | — | 1 | 5.63 |
| CHEMBL146 | BUTYLATED HYDROXYTOLUENE | 2.0 | 1 | 5.49 |
| CHEMBL3706727 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3706732 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL123621 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL333995 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL146 | BUTYLATED HYDROXYTOLUENE | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL3706727 | — | IC50 | = | 3600.0 | nM | 5.44 |