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Assay Detail

CHEMBL800846

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Confidence 9 — Direct single protein target
Curated By Expert

Target

2-5A-dependent ribonuclease (CHEMBL2687)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Synthesis, characterization, and biological properties of 8-azido- and 8-amino-substituted 2',5'-oligoadenylates.
Sawai H, Hirano A, Mori H, Shinozuka K, Dong B, Silverman RH.
J Med Chem (2003) 46 : 4926 -4932
PubMed 14584943 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 7.04 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1163094 1 8.70
CHEMBL2368698 1 8.70
CHEMBL404038 1 8.52
CHEMBL414948 1 8.40
CHEMBL2368696 1 7.30
CHEMBL610609 1 7.16
CHEMBL610855 1 6.30
CHEMBL2368697 1 6.00
CHEMBL607600 1 5.30
CHEMBL2373178 1 4.00
CHEMBL607888 1 -
CHEMBL608161 1 -
CHEMBL607882 1 -
CHEMBL2368694 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1163094 IC50 = 2.0 nM 8.70
CHEMBL2368698 IC50 = 2.0 nM 8.70
CHEMBL404038 IC50 = 3.0 nM 8.52
CHEMBL414948 IC50 = 4.0 nM 8.40
CHEMBL2368696 IC50 = 50.0 nM 7.30
CHEMBL610609 IC50 = 70.0 nM 7.16
CHEMBL610855 IC50 = 500.0 nM 6.30
CHEMBL2368697 IC50 = 1000.0 nM 6.00
CHEMBL607600 IC50 = 5000.0 nM 5.30
CHEMBL2373178 IC50 = 100000.0 nM 4.00
CHEMBL607888 IC50 > 100000.0 nM -
CHEMBL608161 IC50 > 100000.0 nM -
CHEMBL607882 IC50 > 100000.0 nM -
CHEMBL2368694 IC50 > 100000.0 nM -