Compound Detail
CHEMBL1163094
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[N-]=[N+]=Nc1nc2c(N)ncnc2n1C1OC(COP(=O)(O)O)C(O)C1OP(=O)(O)OCC1OC(n2c(N=[N+]=[N-])nc3c(N)ncnc32)C(OP(=O)(O)OC[C@H]2OC(n3c(N=[N+]=[N-])nc4c(N)ncnc43)[C@H](O)[C@@H]2O)C1O
Basic Information
| ChEMBL ID | CHEMBL1163094 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CAAJLEGDAOZENT-TXYPTYCHSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1128.7
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 2-5A-dependent ribonuclease CHEMBL2687 | IC50 | 8.7 | 8.7 | 2.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 2-5A-dependent ribonuclease | IC50 | = | 2.0 | nM | 8.7 | Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L)... | 14584943 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14584943 | 10.1021/jm030035k | 2-5A-dependent ribonuclease | 2 |
Data from ChEMBL 36 via Core Engine