Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL800886

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro binding affinity was determined against NA (noradrenaline) reuptake site of rat in presence of [3H]nisoxetine radioligand
ChEMBL ↗
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Norepinephrine transporter (CHEMBL304) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Potential antidepressants displayed combined alpha(2)-adrenoceptor antagonist and monoamine uptake inhibitor properties.
Cordi AA, Berque-Bestel I, Persigand T, Lacoste JM, Newman-Tancredi A, Audinot V, Millan MJ.
J Med Chem (2001) 44 : 787 -805
PubMed 11262089 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 51 6.80 7.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL262777 VANCOMYCIN 4.0 1 7.80
CHEMBL168168 — — 1 7.70
CHEMBL168022 — — 1 7.60
CHEMBL167578 — — 1 7.50
CHEMBL166448 — — 1 7.50
CHEMBL353843 — — 1 7.40
CHEMBL353828 — — 1 7.40
CHEMBL166226 — — 1 7.30
CHEMBL407509 — — 1 7.30
CHEMBL436234 — — 1 7.30
CHEMBL353200 — — 1 7.30
CHEMBL354112 — — 1 7.20
CHEMBL168000 — — 1 7.20
CHEMBL167644 — — 1 7.20
CHEMBL168153 — — 1 7.10
CHEMBL352643 — — 1 7.00
CHEMBL354611 — — 1 7.00
CHEMBL166748 — — 1 7.00
CHEMBL166690 — — 1 7.00
CHEMBL355467 — — 1 7.00
CHEMBL353139 — — 1 6.90
CHEMBL353705 — — 1 6.80
CHEMBL166648 — — 1 6.70
CHEMBL165529 — — 1 6.70
CHEMBL3037826 — — 1 6.60
CHEMBL166683 — — 1 6.50
CHEMBL168205 — — 1 6.50
CHEMBL90997 — — 1 6.50
CHEMBL167437 — — 1 6.50
CHEMBL165467 — — 1 6.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL262777 VANCOMYCIN Ki = 15.85 nM 7.80
CHEMBL168168 — Ki = 19.95 nM 7.70
CHEMBL168022 — Ki = 25.12 nM 7.60
CHEMBL167578 — Ki = 31.62 nM 7.50
CHEMBL166448 — Ki = 31.62 nM 7.50
CHEMBL353843 — Ki = 39.81 nM 7.40
CHEMBL353828 — Ki = 39.81 nM 7.40
CHEMBL353200 — Ki = 50.12 nM 7.30
CHEMBL436234 — Ki = 50.12 nM 7.30
CHEMBL166226 — Ki = 50.12 nM 7.30
CHEMBL407509 — Ki = 50.12 nM 7.30
CHEMBL167644 — Ki = 63.1 nM 7.20
CHEMBL168000 — Ki = 63.1 nM 7.20
CHEMBL354112 — Ki = 63.1 nM 7.20
CHEMBL168153 — Ki = 79.43 nM 7.10
CHEMBL352643 — Ki = 100.0 nM 7.00
CHEMBL355467 — Ki = 100.0 nM 7.00
CHEMBL166690 — Ki = 100.0 nM 7.00
CHEMBL166748 — Ki = 100.0 nM 7.00
CHEMBL354611 — Ki = 100.0 nM 7.00
CHEMBL353139 — Ki = 125.89 nM 6.90
CHEMBL353705 — Ki = 158.49 nM 6.80
CHEMBL166648 — Ki = 199.53 nM 6.70
CHEMBL165529 — Ki = 199.53 nM 6.70
CHEMBL3037826 — Ki = 251.19 nM 6.60
CHEMBL166683 — Ki = 316.23 nM 6.50
CHEMBL167437 — Ki = 316.23 nM 6.50
CHEMBL168205 — Ki = 316.23 nM 6.50
CHEMBL90997 — Ki = 316.23 nM 6.50
CHEMBL165467 — Ki = 398.11 nM 6.40
CHEMBL166852 — Ki = 501.19 nM 6.30
CHEMBL165645 — Ki = 794.33 nM 6.10
CHEMBL168201 — Ki = 794.33 nM 6.10
CHEMBL166501 — Ki = 794.33 nM 6.10
CHEMBL41 FLUOXETINE Ki = 794.33 nM 6.10
CHEMBL353212 — Ki = 794.33 nM 6.10
CHEMBL354072 — Ki = 1000.0 nM 6.00
CHEMBL167515 — Ki = 1000.0 nM 6.00
CHEMBL167649 — Ki = 1000.0 nM 6.00
CHEMBL352636 — Ki = 1000.0 nM 6.00
CHEMBL164118 — Ki = 1000.0 nM 6.00
CHEMBL167394 — Ki < 1000.0 nM -
CHEMBL167749 — Ki < 1000.0 nM -
CHEMBL167795 — Ki < 10000.0 nM -
CHEMBL352704 — Ki < 10000.0 nM -
CHEMBL353910 — Ki < 1000.0 nM -
CHEMBL424557 — Ki < 1000.0 nM -
CHEMBL168063 — Ki < 1000.0 nM -
CHEMBL167493 NAPAMEZOLE Ki < 1000.0 nM -
CHEMBL353972 ATIPAMEZOLE Ki < 10000.0 nM -