Assay Detail
Binding
CHEMBL800982
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Inhibitory concentration against HIV-1 replication by interfering with virus reverse transcriptase
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Comparative molecular moment analysis (CoMMA): 3D-QSAR without molecular superposition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.18 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58711 | TIVIRAPINE | 2.0 | 1 | 8.30 |
| CHEMBL66155 | — | — | 1 | 7.92 |
| CHEMBL304294 | — | — | 1 | 7.64 |
| CHEMBL66350 | — | — | 1 | 7.58 |
| CHEMBL69566 | — | — | 1 | 7.47 |
| CHEMBL303015 | — | — | 1 | 7.38 |
| CHEMBL296092 | TIBO | — | 1 | 7.37 |
| CHEMBL420367 | — | — | 1 | 7.34 |
| CHEMBL66434 | — | — | 1 | 7.22 |
| CHEMBL65881 | — | — | 1 | 7.11 |
| CHEMBL46961 | — | — | 1 | 7.01 |
| CHEMBL420740 | — | — | 1 | 6.84 |
| CHEMBL69674 | — | — | 1 | 6.80 |
| CHEMBL307994 | — | — | 1 | 6.80 |
| CHEMBL67675 | — | — | 1 | 6.75 |
| CHEMBL304826 | — | — | 1 | 6.64 |
| CHEMBL308644 | — | — | 1 | 6.32 |
| CHEMBL308222 | — | — | 1 | 6.17 |
| CHEMBL303241 | — | — | 1 | 5.94 |
| CHEMBL67451 | — | — | 1 | 5.78 |
| CHEMBL66704 | — | — | 1 | 5.66 |
| CHEMBL66043 | — | — | 1 | 5.65 |
| CHEMBL65800 | — | — | 1 | 5.61 |
| CHEMBL66404 | — | — | 1 | 5.48 |
| CHEMBL69517 | — | — | 1 | 4.92 |
| CHEMBL69775 | — | — | 1 | 4.90 |
| CHEMBL68933 | — | — | 1 | 4.87 |
| CHEMBL305070 | — | — | 1 | 4.59 |
| CHEMBL68175 | — | — | 1 | 4.49 |
| CHEMBL65801 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58711 | TIVIRAPINE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL66155 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL304294 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL66350 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL69566 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL303015 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL296092 | TIBO | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL420367 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL66434 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL65881 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL46961 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL420740 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL69674 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL307994 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL67675 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL304826 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL308644 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL308222 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL303241 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL67451 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL66704 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL66043 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL65800 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL66404 | — | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL69517 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL69775 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL68933 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL305070 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL68175 | — | IC50 | = | 32100.0 | nM | 4.49 |
| CHEMBL65801 | — | IC50 | = | 34700.0 | nM | 4.46 |
| CHEMBL304317 | — | IC50 | = | 48100.0 | nM | 4.32 |
| CHEMBL304331 | — | IC50 | = | 56700.0 | nM | 4.25 |
| CHEMBL66377 | — | IC50 | = | 59700.0 | nM | 4.22 |