Compound Detail
CHEMBL296092
TIBO Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL296092 |
| Name | TIBO |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RCSLUNOLLUVOOG-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
321.9
MW (Da)
4.15
ALogP
4
HBA
1
HBD
21.1
PSA (Ų)
0.66
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.48
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human immunodeficiency virus 1 CHEMBL378 | IC50 | 7.48 | 7.48 | 33.0 | 1 |
| Human immunodeficiency virus type 1 reverse transcriptase CHEMBL247 | IC50 | 7.37 | 7.37 | 43.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Human immunodeficiency virus 1 | IC50 | = | 33.0 | nM | 7.48 | Concentration required to inhibit 50% viral production of human immunodeficiency... | 15801834 |
| Human immunodeficiency virus type 1 reverse transcriptase | IC50 | = | 43.0 | nM | 7.37 | Inhibitory concentration against HIV-1 replication by interfering with virus rev... | 8667357 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(00)80447-3 | MT2 | 4 |
| 8667357 | 10.1021/jm950589q | Human immunodeficiency virus type 1 reverse transcriptase | 1 |
| 15801834 | 10.1021/jm049606e | Human immunodeficiency virus 1 | 1 |
| - | 10.1007/s00044-011-9742-x | Human immunodeficiency virus type 1 reverse transcriptase | 1 |
Data from ChEMBL 36 via Core Engine