Assay Detail
Functional
CHEMBL801194
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In vitro cytotoxicity was tested against human Ovarian carcinoma SKOV-3 cell line
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
2,3-Dihydro-1H,7H-pyrimido[5,6,1-de]acridine-1,3,7-trione derivatives, a class of cytotoxic agents active on multidrug-resistant cell lines: synthesis, biological evaluation, and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.34 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL544311 | — | — | 1 | 7.38 |
| CHEMBL553593 | — | — | 1 | 7.34 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.11 |
| CHEMBL553744 | — | — | 1 | 6.92 |
| CHEMBL82722 | — | — | 1 | 6.85 |
| CHEMBL85471 | — | — | 1 | 6.80 |
| CHEMBL85087 | — | — | 1 | 6.25 |
| CHEMBL83620 | — | — | 1 | 6.24 |
| CHEMBL84219 | — | — | 1 | 5.87 |
| CHEMBL432951 | — | — | 1 | 5.47 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 5.47 |
| CHEMBL82952 | — | — | 1 | 5.42 |
| CHEMBL83128 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL544311 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL553593 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL553744 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL82722 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL85471 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL85087 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL83620 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL84219 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL432951 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL82952 | — | IC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL83128 | — | IC50 | = | 4700.0 | nM | 5.33 |