Assay Detail
Binding
CHEMBL801376
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for Retinoic acid receptor RXR-gamma was determined by competing with 3[H]-9-cis-RA
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Retinoic acid receptor RXR-gamma (CHEMBL4277) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.88 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340074 | — | — | 1 | 8.72 |
| CHEMBL340555 | — | — | 1 | 8.60 |
| CHEMBL339298 | — | — | 1 | 8.31 |
| CHEMBL133176 | — | — | 1 | 8.31 |
| CHEMBL335751 | — | — | 1 | 8.18 |
| CHEMBL129887 | — | — | 1 | 8.16 |
| CHEMBL336086 | — | — | 1 | 8.12 |
| CHEMBL131561 | — | — | 1 | 8.00 |
| CHEMBL42314 | — | — | 1 | 7.92 |
| CHEMBL335762 | — | — | 1 | 7.86 |
| CHEMBL337719 | — | — | 1 | 7.80 |
| CHEMBL288436 | — | — | 1 | 7.75 |
| CHEMBL132488 | — | — | 1 | 7.74 |
| CHEMBL445634 | — | — | 1 | 7.31 |
| CHEMBL130577 | — | — | 1 | 7.20 |
| CHEMBL130230 | — | — | 1 | 7.13 |
| CHEMBL129976 | — | — | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340074 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL340555 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL339298 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL133176 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL335751 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL129887 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL336086 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL131561 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL42314 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL335762 | — | Ki | = | 13.9 | nM | 7.86 |
| CHEMBL337719 | — | Ki | = | 15.9 | nM | 7.80 |
| CHEMBL288436 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL132488 | — | Ki | = | 18.1 | nM | 7.74 |
| CHEMBL445634 | — | Ki | = | 48.6 | nM | 7.31 |
| CHEMBL130577 | — | Ki | = | 63.2 | nM | 7.20 |
| CHEMBL130230 | — | Ki | = | 73.9 | nM | 7.13 |
| CHEMBL129976 | — | Ki | = | 154.7 | nM | 6.81 |