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Assay Detail

CHEMBL801380

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Binding
Effective concentrations against Retinoic acid receptor RXR-gamma
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Retinoic acid receptor RXR-gamma (CHEMBL2004)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity.
Dawson MI, Jong L, Hobbs PD, Cameron JF, Chao WR, Pfahl M, Lee MO, Shroot B, Pfahl M.
J Med Chem (1995) 38 : 3368 -3383
PubMed 7650690 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 13 6.73 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL96184 1 8.70
CHEMBL38 TRETINOIN 4.0 1 8.70
CHEMBL705 ALITRETINOIN 4.0 1 8.37
CHEMBL1023 BEXAROTENE 4.0 1 6.91
CHEMBL114880 1 6.52
CHEMBL115050 1 6.43
CHEMBL111983 1 6.28
CHEMBL414233 1 6.28
CHEMBL116859 1 6.28
CHEMBL98172 1 5.92
CHEMBL101308 1 5.77
CHEMBL114390 1 5.70
CHEMBL111911 1 5.64

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL96184 EC50 = 2.0 nM 8.70
CHEMBL38 TRETINOIN EC50 = 2.0 nM 8.70
CHEMBL705 ALITRETINOIN EC50 = 4.3 nM 8.37
CHEMBL1023 BEXAROTENE EC50 = 122.0 nM 6.91
CHEMBL114880 EC50 = 300.0 nM 6.52
CHEMBL115050 EC50 = 370.0 nM 6.43
CHEMBL111983 EC50 = 520.0 nM 6.28
CHEMBL414233 EC50 = 520.0 nM 6.28
CHEMBL116859 EC50 = 530.0 nM 6.28
CHEMBL98172 EC50 = 1200.0 nM 5.92
CHEMBL101308 EC50 = 1700.0 nM 5.77
CHEMBL114390 EC50 = 2000.0 nM 5.70
CHEMBL111911 EC50 = 2300.0 nM 5.64