Assay Detail
Binding
CHEMBL801674
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Inhibitory activity against human renin
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Renin inhibitors. Design and synthesis of a new class of conformationally restricted analogues of angiotensinogen.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.57 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL321937 | — | — | 1 | 6.55 |
| CHEMBL318242 | — | — | 1 | 5.92 |
| CHEMBL101874 | — | — | 1 | 5.85 |
| CHEMBL433013 | — | — | 1 | 5.57 |
| CHEMBL98582 | — | — | 1 | 5.34 |
| CHEMBL97865 | — | — | 1 | 4.16 |
| CHEMBL445118 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL321937 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL318242 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL101874 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL433013 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL98582 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL97865 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL445118 | — | IC50 | > | 100000.0 | nM | - |