Assay Detail
Binding
CHEMBL801708
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In vitro inhibitory activity against human plasma renin
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design, structure-activity, and molecular modeling studies of potent renin inhibitory peptides having N-terminal Nin-For-Trp (Ftr): angiotensinogen congeners modified by P1-P1' Phe-Phe, Sta, Leu psi[CH(OH)CH2]Val or leu psi[CH2NH]Val substitutions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.56 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL419531 | — | — | 1 | 10.00 |
| CHEMBL1790497 | DITEKIREN | 2.0 | 1 | 9.96 |
| CHEMBL320414 | — | — | 1 | 9.51 |
| CHEMBL275711 | — | — | 1 | 9.42 |
| CHEMBL318388 | — | — | 1 | 9.28 |
| CHEMBL216847 | — | — | 1 | 9.00 |
| CHEMBL317280 | — | — | 1 | 8.80 |
| CHEMBL100924 | — | — | 1 | 8.42 |
| CHEMBL329933 | — | — | 1 | 8.17 |
| CHEMBL407670 | — | — | 1 | 8.00 |
| CHEMBL330412 | — | — | 1 | 7.85 |
| CHEMBL437836 | — | — | 1 | 7.80 |
| CHEMBL316921 | — | — | 1 | 7.68 |
| CHEMBL329982 | — | — | 1 | 7.51 |
| CHEMBL263739 | — | — | 1 | 6.30 |
| CHEMBL415839 | — | — | 1 | 5.68 |
| CHEMBL262208 | — | — | 1 | 5.30 |
| CHEMBL316614 | — | — | 1 | 5.24 |
| CHEMBL413534 | RIP | — | 1 | 5.10 |
| CHEMBL265165 | — | — | 1 | 5.08 |
| CHEMBL296588 | PEPSTATIN | 2.0 | 1 | 4.66 |
| CHEMBL436895 | — | — | 1 | - |
| CHEMBL217629 | — | — | 1 | - |
| CHEMBL420276 | — | — | 1 | - |
| CHEMBL2370339 | — | — | 1 | - |
| CHEMBL437516 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL419531 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL1790497 | DITEKIREN | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL320414 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL275711 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL318388 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL216847 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL317280 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL100924 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL329933 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL407670 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL330412 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL437836 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL316921 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL329982 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL263739 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL415839 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL262208 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL316614 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL413534 | RIP | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL265165 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL296588 | PEPSTATIN | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL436895 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL217629 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL420276 | — | IC50 | ~ | 100000.0 | nM | - |
| CHEMBL2370339 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL437516 | — | IC50 | > | 100000.0 | nM | - |