Compound Detail
CHEMBL413534
RIP Enter ChEMBL ID:
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CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)O
Basic Information
| ChEMBL ID | CHEMBL413534 |
| Name | RIP |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | XPAHSKSBHMOJNZ-DIAUVYRXSA-N |
2
Targets
7
Activities
1
Assay Types
0
PK Parameters
15
Publications
0
Known Names
Molecular Properties
1465.7
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 5.28
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Renin CHEMBL286 | IC50 | 5.28 | 5.12 | 5200.0 | 5 |
| Angiotensin-converting enzyme CHEMBL4074 | IC50 | 4.92 | 4.92 | 12000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Renin | IC50 | = | 5200.0 | nM | 5.28 | Inhibitory activity against human plasma renin | 3302256 |
| Renin | IC50 | = | 7000.0 | nM | 5.16 | Inhibition of Human plasma renin | 3279210 |
| Renin | IC50 | = | 8000.0 | nM | 5.1 | In vitro inhibitory activity against human plasma renin | 3275777 |
| Renin | IC50 | = | 9410.0 | nM | 5.03 | Plasma renin inhibitory activity was evaluated in lyophilized human plasma with ... | 3906126 |
| Renin | IC50 | = | 9400.0 | nM | 5.03 | Compound was tested for inhibition of human plasma renin. | 3531517 |
| Angiotensin-converting enzyme | IC50 | = | 12000.0 | nM | 4.92 | Inhibitory activity was evaluated against Angiotensin I converting enzyme activi... | 3906126 |
| Angiotensin-converting enzyme | IC50 | = | 12000.0 | nM | 4.92 | Compound was tested for inhibition of Angiotensin I converting enzyme from rabbi... | 3531517 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 3275777 | 10.1021/jm00396a006 | Renin | 2 |
| 3906126 | 10.1021/jm00149a001 | Renin | 1 |
| 3906126 | 10.1021/jm00149a001 | Pepsin A | 1 |
| 3906126 | 10.1021/jm00149a001 | Cathepsin D | 1 |
| 3906126 | 10.1021/jm00149a001 | Angiotensin-converting enzyme | 1 |
| 3302256 | 10.1021/jm00391a005 | Renin | 1 |
| 3531517 | 10.1021/jm00160a048 | Renin | 1 |
| 3531517 | 10.1021/jm00160a048 | Pepsin A | 1 |
| 3531517 | 10.1021/jm00160a048 | Cathepsin D | 1 |
| 3531517 | 10.1021/jm00160a048 | Angiotensin-converting enzyme | 1 |
| 3279210 | 10.1021/jm00398a029 | Renin | 1 |
| 3279210 | 10.1021/jm00398a029 | Unchecked | 1 |
| 3279210 | 10.1021/jm00398a029 | Chymotrypsinogen A | 1 |
| 3279210 | 10.1021/jm00398a029 | Homo sapiens | 1 |
| 3279210 | 10.1021/jm00398a029 | Pepsin A | 1 |
Data from ChEMBL 36 via Core Engine