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Assay Detail

CHEMBL803436

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Human plasma renin
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Plasma
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Renin (CHEMBL286)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Renin inhibitors containing psi[CH2O] pseudopeptide inserts.
TenBrink RE, Pals DT, Harris DW, Johnson GA.
J Med Chem (1988) 31 : 671 -677
PubMed 3279210 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.75 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL407670 1 8.00
CHEMBL264264 1 7.30
CHEMBL161322 1 6.44
CHEMBL268104 1 5.80
CHEMBL266400 1 5.77
CHEMBL386106 1 5.75
CHEMBL345615 1 5.64
CHEMBL415368 1 5.52
CHEMBL422190 1 5.39
CHEMBL435454 1 5.24
CHEMBL413534 RIP 1 5.16
CHEMBL262799 1 4.75
CHEMBL407901 1 4.00
CHEMBL413362 1 -
CHEMBL265970 1 -
CHEMBL347572 1 -
CHEMBL437229 1 -
CHEMBL347694 1 -
CHEMBL263293 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL407670 IC50 = 10.0 nM 8.00
CHEMBL264264 IC50 = 50.0 nM 7.30
CHEMBL161322 IC50 = 360.0 nM 6.44
CHEMBL268104 IC50 = 1600.0 nM 5.80
CHEMBL266400 IC50 = 1700.0 nM 5.77
CHEMBL386106 IC50 = 1800.0 nM 5.75
CHEMBL345615 IC50 = 2300.0 nM 5.64
CHEMBL415368 IC50 = 3000.0 nM 5.52
CHEMBL422190 IC50 = 4100.0 nM 5.39
CHEMBL435454 IC50 = 5800.0 nM 5.24
CHEMBL413534 RIP IC50 = 7000.0 nM 5.16
CHEMBL262799 IC50 = 18000.0 nM 4.75
CHEMBL407901 IC50 = 100000.0 nM 4.00
CHEMBL413362 IC50 = 330000.0 nM -
CHEMBL265970 IC50 = 440000.0 nM -
CHEMBL347572 IC50 = 140000.0 nM -
CHEMBL437229 IC50 = 1000000.0 nM -
CHEMBL347694 IC50 = 2500000.0 nM -
CHEMBL263293 IC50 = 550000.0 nM -