Compound Detail
CHEMBL386106
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CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)OC[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](CCCCN)C(=O)O
Basic Information
| ChEMBL ID | CHEMBL386106 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CSGZRYIDMIQJMO-JMGKPLBVSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1225.5
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Renin CHEMBL286 | IC50 | 5.75 | 5.75 | 1800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Renin | IC50 | = | 1800.0 | nM | 5.75 | Inhibition of Human plasma renin | 3279210 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 3279210 | 10.1021/jm00398a029 | Renin | 1 |
Data from ChEMBL 36 via Core Engine