Assay Detail
Binding
CHEMBL806860
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Plasma renin inhibitory activity was evaluated in lyophilized human plasma with 0.1%EDTA
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Difluorostatine- and difluorostatone-containing peptides as potent and specific renin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.12 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3143966 | — | — | 1 | 9.28 |
| CHEMBL57121 | — | — | 1 | 8.77 |
| CHEMBL427581 | — | — | 1 | 7.92 |
| CHEMBL3143967 | — | — | 1 | 7.47 |
| CHEMBL57399 | — | — | 1 | 6.14 |
| CHEMBL296588 | PEPSTATIN | 2.0 | 1 | 5.22 |
| CHEMBL413534 | RIP | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3143966 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL57121 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL427581 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3143967 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL57399 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL296588 | PEPSTATIN | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL413534 | RIP | IC50 | = | 9410.0 | nM | 5.03 |