Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL801733

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Concentration required to inhibit renal dipeptidase (RDP) by 50% in crude lysates prepared from human colon cancer
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Dipeptidase 1 (CHEMBL1989)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and evaluation of aminophosphinic acid derivatives as inhibitors of renal dipeptidase.
Gurulingappa H, Buckhalts P, Kinzler KW, Vogelstein B, Khan SR.
Bioorg Med Chem Lett (2004) 14 : 3531 -3533
PubMed 15177467 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 7.22 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL119723 1 8.30
CHEMBL117337 1 8.22
CHEMBL326292 1 8.10
CHEMBL333841 1 8.00
CHEMBL119055 1 7.82
CHEMBL332970 1 7.70
CHEMBL334279 1 7.60
CHEMBL120600 1 7.52
CHEMBL334143 1 7.52
CHEMBL332290 1 7.40
CHEMBL122415 1 7.35
CHEMBL119261 1 7.16
CHEMBL325021 1 7.00
CHEMBL120198 1 6.82
CHEMBL119118 1 6.70
CHEMBL420537 1 6.70
CHEMBL118190 1 6.60
CHEMBL119392 1 6.46
CHEMBL331554 1 6.00
CHEMBL118275 1 5.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL119723 IC50 = 5.0 nM 8.30
CHEMBL117337 IC50 = 6.0 nM 8.22
CHEMBL326292 IC50 = 8.0 nM 8.10
CHEMBL333841 IC50 = 10.0 nM 8.00
CHEMBL119055 IC50 = 15.0 nM 7.82
CHEMBL332970 IC50 = 20.0 nM 7.70
CHEMBL334279 IC50 = 25.0 nM 7.60
CHEMBL120600 IC50 = 30.0 nM 7.52
CHEMBL334143 IC50 = 30.0 nM 7.52
CHEMBL332290 IC50 = 40.0 nM 7.40
CHEMBL122415 IC50 = 45.0 nM 7.35
CHEMBL119261 IC50 = 70.0 nM 7.16
CHEMBL325021 IC50 = 100.0 nM 7.00
CHEMBL120198 IC50 = 150.0 nM 6.82
CHEMBL119118 IC50 = 200.0 nM 6.70
CHEMBL420537 IC50 = 200.0 nM 6.70
CHEMBL118190 IC50 = 250.0 nM 6.60
CHEMBL119392 IC50 = 350.0 nM 6.46
CHEMBL331554 IC50 = 1000.0 nM 6.00
CHEMBL118275 IC50 = 3000.0 nM 5.52