Assay Detail
Binding
CHEMBL801739
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Concentration required to inhibit the maximum [14C]Gly-Sar uptake by Renal peptide transporter PepT2 in SKPT cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | SKPT |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Phe-Gly dipeptidomimetics designed for the di-/tripeptide transporters PEPT1 and PEPT2: synthesis and biological investigations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.65 | 4.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429950 | — | — | 1 | 4.81 |
| CHEMBL417979 | — | — | 1 | 4.76 |
| CHEMBL10650 | — | — | 1 | 4.65 |
| CHEMBL1727 | CEPHALEXIN ANHYDROUS | 4.0 | 1 | 4.38 |
| CHEMBL274764 | — | — | 1 | - |
| CHEMBL10729 | — | — | 1 | - |
| CHEMBL10717 | — | — | 1 | - |
| CHEMBL269212 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429950 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL417979 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL10650 | — | IC50 | = | 22200.0 | nM | 4.65 |
| CHEMBL1727 | CEPHALEXIN ANHYDROUS | IC50 | = | 41600.0 | nM | 4.38 |
| CHEMBL274764 | — | IC50 | = | 1594000.0 | nM | - |
| CHEMBL10729 | — | IC50 | = | 8176000.0 | nM | - |
| CHEMBL10717 | — | IC50 | = | 4111000.0 | nM | - |
| CHEMBL269212 | — | IC50 | = | 8802000.0 | nM | - |