Assay Detail
Binding
CHEMBL801815
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Transcriptional activation in CV-1 cells expressing retinoid A receptor RAR alpha
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Conformationally defined retinoic acid analogues. 4. Potential new agents for acute promyelocytic and juvenile myelomonocytic leukemias.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.55 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44478 | — | — | 1 | 7.75 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 7.66 |
| CHEMBL46398 | — | — | 1 | 7.48 |
| CHEMBL44582 | — | — | 1 | 7.29 |
| CHEMBL44979 | — | — | 1 | - |
| CHEMBL296193 | — | — | 1 | - |
| CHEMBL46397 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44478 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL38 | TRETINOIN | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL46398 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL44582 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL44979 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL296193 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL46397 | — | EC50 | > | 2000.0 | nM | - |