Assay Detail
Binding
CHEMBL801817
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Inhibition of [3H]ATRA binding to mouse Retinoic acid receptor RAR alpha
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Conformationally defined 6-s-trans-retinoic acid analogs. 3. Structure-activity relationships for nuclear receptor binding, transcriptional activity, and cancer chemopreventive activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.55 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 8.22 |
| CHEMBL333032 | — | — | 1 | 8.10 |
| CHEMBL46398 | — | — | 1 | 7.96 |
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 7.51 |
| CHEMBL122823 | — | — | 1 | 7.26 |
| CHEMBL121659 | — | — | 1 | 6.22 |
| CHEMBL2111792 | — | — | 1 | - |
| CHEMBL2114968 | — | — | 1 | - |
| CHEMBL2111790 | — | — | 1 | - |
| CHEMBL2111791 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL333032 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL46398 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL705 | ALITRETINOIN | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL122823 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL121659 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2111792 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL2114968 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2111790 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2111791 | — | IC50 | > | 2000.0 | nM | - |