Assay Detail
Functional
CHEMBL801864
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Ability to protect cerebellar granule cells (CGC) from iodoacetate (IAA)-induced toxicity
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
3,5-Disubstituted-4-hydroxyphenyls linked to 3-hydroxy-2-methyl-4(1H)-pyridinone: potent inhibitors of lipid peroxidation and cell toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.37 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96250 | — | — | 1 | 6.52 |
| CHEMBL415316 | — | — | 1 | 6.52 |
| CHEMBL93440 | — | — | 1 | 6.40 |
| CHEMBL318038 | — | — | 1 | 6.22 |
| CHEMBL96606 | — | — | 1 | 5.30 |
| CHEMBL146 | BUTYLATED HYDROXYTOLUENE | 2.0 | 1 | 5.22 |
| CHEMBL94331 | — | — | 1 | 4.57 |
| CHEMBL319659 | — | — | 1 | 4.48 |
| CHEMBL70927 | DEFERIPRONE | 4.0 | 1 | 4.33 |
| CHEMBL153 | TROLOX | — | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96250 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL415316 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL93440 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL318038 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL96606 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL146 | BUTYLATED HYDROXYTOLUENE | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL94331 | — | EC50 | = | 26800.0 | nM | 4.57 |
| CHEMBL319659 | — | EC50 | = | 33300.0 | nM | 4.48 |
| CHEMBL70927 | DEFERIPRONE | EC50 | = | 46700.0 | nM | 4.33 |
| CHEMBL153 | TROLOX | EC50 | = | 77800.0 | nM | 4.11 |