Assay Detail
Binding
CHEMBL802399
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Antiviral activity was tested in cells acutely infected with HIV-1 RT (reverse transcriptase)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Deoxy sugar analogues of triciribine: correlation of antiviral and antiproliferative activity with intracellular phosphorylation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.49 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL462018 | TRICIRIBINE PHOSPHATE | 2.0 | 1 | 7.40 |
| CHEMBL331237 | TRICIRIBINE | — | 1 | 7.40 |
| CHEMBL2112098 | — | — | 1 | 4.68 |
| CHEMBL314567 | — | — | 1 | - |
| CHEMBL2367598 | — | — | 1 | - |
| CHEMBL1790617 | — | — | 1 | - |
| CHEMBL609194 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL462018 | TRICIRIBINE PHOSPHATE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL331237 | TRICIRIBINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2112098 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL314567 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2367598 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1790617 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL609194 | — | IC50 | > | 100000.0 | nM | - |