Compound Detail
CHEMBL331237
TRICIRIBINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL331237 |
| Name | TRICIRIBINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HOGVTUZUJGHKPL-HTVVRFAVSA-N |
14
Targets
57
Activities
3
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
320.3
MW (Da)
-1.89
ALogP
10
HBA
4
HBD
142.2
PSA (Ų)
0.50
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 55 meas. best 8.7
EC50 1 meas. best 5.7
Kd 1 meas.
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human immunodeficiency virus 1 CHEMBL378 | IC50 | 8.7 | 7.0858 | 2.0 | 31 |
| Human immunodeficiency virus 2 CHEMBL380 | IC50 | 8.22 | 7.3675 | 6.0 | 4 |
| Human immunodeficiency virus type 1 reverse transcriptase CHEMBL247 | IC50 | 7.7 | 7.475 | 20.0 | 4 |
| Human immunodeficiency virus CHEMBL613758 | IC50 | 7.7 | 7.7 | 20.0 | 1 |
| L1210 CHEMBL386 | IC50 | 7.46 | 7.46 | 35.0 | 1 |
| Simian immunodeficiency virus CHEMBL613499 | IC50 | 7.4 | 7.31 | 40.0 | 2 |
| Huh-7 CHEMBL614039 | EC50 | 5.7 | 5.7 | 2000.0 | 1 |
| Histone deacetylase 6 CHEMBL1865 | IC50 | 5.6 | 5.6 | 2521.0 | 1 |
| Human betaherpesvirus 5 CHEMBL371 | IC50 | 5.6 | 5.6 | 2500.0 | 1 |
| HFF CHEMBL614071 | IC50 | 5.6 | 4.64 | 2500.0 | 5 |
| H9 CHEMBL614806 | IC50 | 4.79 | 4.79 | 16300.0 | 1 |
| Human alphaherpesvirus 1 CHEMBL377 | IC50 | 4.64 | 4.64 | 23000.0 | 1 |
| ADMET CHEMBL612558 | IC50 | 4.64 | 4.64 | 23000.0 | 2 |
| KB CHEMBL398 | IC50 | 4.0 | 4.0 | 100000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine