Assay Detail

CHEMBL1676719

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Functional

Antiviral activity against simian immunodeficiency virus 69R infected in phytohemagglutininin and interleukin-2-stimulated PBMC assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay

ChEMBL ↗

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Target

Simian immunodeficiency virus (CHEMBL613499) ↗

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Primary target Simian immunodeficiency virus

CHEMBL613499

Anchored from Assay target.

Protein identity Simian immunodeficiency virus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Simian immunodeficiency virus
Confidence	1 — Organism
Curated By	Autocuration

Target

Simian immunodeficiency virus (CHEMBL613499) ↗

Type	ORGANISM
Organism	Simian immunodeficiency virus

Publication

Inhibition of human immunodeficiency virus type 1 by triciribine involves the accessory protein nef.

Ptak RG, Gentry BG, Hartman TL, Watson KM, Osterling MC, Buckheit RW, Townsend LB, Drach JC.
Antimicrob Agents Chemother (2010) 54 : 1512 -1519
PubMed 20086149 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.35	9.30

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL129	ZIDOVUDINE	4.0	1	9.30
CHEMBL331237	TRICIRIBINE	—	1	7.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL129	ZIDOVUDINE	IC50	=	0.5	nM	9.30
CHEMBL331237	TRICIRIBINE	IC50	=	40.0	nM	7.40