Assay Detail
Binding
CHEMBL802397
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity was evaluated by RT (reverse transcriptase) activity in cells acutely infected with HIV-1
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
6-N-Acyltriciribine analogues: structure-activity relationship between acyl carbon chain length and activity against HIV-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.27 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL608901 | — | — | 1 | 7.46 |
| CHEMBL462018 | TRICIRIBINE PHOSPHATE | 2.0 | 1 | 7.40 |
| CHEMBL331237 | TRICIRIBINE | — | 1 | 7.40 |
| CHEMBL611245 | — | — | 1 | 6.46 |
| CHEMBL611242 | — | — | 1 | 6.30 |
| CHEMBL608301 | — | — | 1 | 6.10 |
| CHEMBL610949 | — | — | 1 | 5.17 |
| CHEMBL610657 | — | — | 1 | 5.10 |
| CHEMBL609191 | — | — | 1 | 5.08 |
| CHEMBL608900 | — | — | 1 | - |
| CHEMBL610370 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL608901 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL462018 | TRICIRIBINE PHOSPHATE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL331237 | TRICIRIBINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL611245 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL611242 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL608301 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL610949 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL610657 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL609191 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL608900 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL610370 | — | IC50 | > | 100000.0 | nM | - |