Compound Detail
CHEMBL610949
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Basic Information
| ChEMBL ID | CHEMBL610949 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PFPFKBWRGWEVAN-LUPRYYEXSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
362.4
MW (Da)
-1.71
ALogP
10
HBA
4
HBD
145.3
PSA (Ų)
0.49
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase CHEMBL247 | IC50 | 5.17 | 5.17 | 6800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase | IC50 | = | 6800.0 | nM | 5.17 | Antiviral activity was evaluated by RT (reverse transcriptase) activity in cells... | 10882373 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10882373 | 10.1021/jm990236h | ADMET | 2 |
| 10882373 | 10.1021/jm990236h | HFF | 2 |
| 10882373 | 10.1021/jm990236h | Human immunodeficiency virus type 1 reverse transcriptase | 1 |
| 10882373 | 10.1021/jm990236h | CEM-SS | 1 |
Data from ChEMBL 36 via Core Engine