Assay Detail

CHEMBL1676716

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Functional

Antiviral activity against Human immunodeficiency virus 2 CDC 310319 infected in phytohemagglutininin and interleukin-2-stimulated PBMC assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay

ChEMBL ↗

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Target

Human immunodeficiency virus 2 (CHEMBL380) ↗

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Primary target Human immunodeficiency virus 2

CHEMBL380

Anchored from Assay target.

Protein identity Human immunodeficiency virus 2

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human immunodeficiency virus 2
Confidence	1 — Organism
Curated By	Autocuration

Target

Human immunodeficiency virus 2 (CHEMBL380) ↗

Type	ORGANISM
Organism	Human immunodeficiency virus 2

Publication

Inhibition of human immunodeficiency virus type 1 by triciribine involves the accessory protein nef.

Ptak RG, Gentry BG, Hartman TL, Watson KM, Osterling MC, Buckheit RW, Townsend LB, Drach JC.
Antimicrob Agents Chemother (2010) 54 : 1512 -1519
PubMed 20086149 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.96	9.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL129	ZIDOVUDINE	4.0	1	9.70
CHEMBL331237	TRICIRIBINE	—	1	8.22

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL129	ZIDOVUDINE	IC50	=	0.2	nM	9.70
CHEMBL331237	TRICIRIBINE	IC50	=	6.0	nM	8.22