Assay Detail
Binding
CHEMBL802597
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Inhibitory activity against HIV-1 Reverse Transcriptase with rCdG as the template primer
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
The biological effects of structural variation at the meta position of the aromatic rings and at the end of the alkenyl chain in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 5.49 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL133772 | — | — | 1 | 7.80 |
| CHEMBL131518 | — | — | 1 | 6.74 |
| CHEMBL129835 | — | — | 1 | 6.63 |
| CHEMBL107200 | — | — | 1 | 6.52 |
| CHEMBL340869 | — | — | 1 | 6.45 |
| CHEMBL58542 | — | — | 1 | 6.42 |
| CHEMBL131761 | — | — | 1 | 6.30 |
| CHEMBL133010 | — | — | 1 | 6.16 |
| CHEMBL335768 | — | — | 1 | 6.00 |
| CHEMBL335037 | — | — | 1 | 5.71 |
| CHEMBL132489 | — | — | 1 | 5.62 |
| CHEMBL133393 | — | — | 1 | 5.53 |
| CHEMBL63497 | — | — | 1 | 5.50 |
| CHEMBL133678 | — | — | 1 | 5.35 |
| CHEMBL130316 | — | — | 1 | 5.31 |
| CHEMBL130336 | — | — | 1 | 5.25 |
| CHEMBL325757 | — | — | 1 | 5.22 |
| CHEMBL264639 | — | — | 1 | 5.15 |
| CHEMBL326205 | — | — | 1 | 5.08 |
| CHEMBL323016 | — | — | 1 | 5.04 |
| CHEMBL132790 | — | — | 1 | 5.02 |
| CHEMBL131432 | — | — | 1 | 5.00 |
| CHEMBL305535 | — | — | 1 | 4.96 |
| CHEMBL106414 | — | — | 1 | 4.53 |
| CHEMBL323276 | — | — | 1 | 4.22 |
| CHEMBL133842 | — | — | 1 | 4.18 |
| CHEMBL323259 | — | — | 1 | 4.15 |
| CHEMBL108267 | — | — | 1 | 4.00 |
| CHEMBL130934 | — | — | 1 | - |
| CHEMBL339176 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL133772 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL131518 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL129835 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL107200 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL340869 | — | IC50 | = | 359.0 | nM | 6.45 |
| CHEMBL58542 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL131761 | — | IC50 | = | 499.0 | nM | 6.30 |
| CHEMBL133010 | — | IC50 | = | 687.0 | nM | 6.16 |
| CHEMBL335768 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL335037 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL132489 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL133393 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL63497 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL133678 | — | IC50 | = | 4430.0 | nM | 5.35 |
| CHEMBL130316 | — | IC50 | = | 4930.0 | nM | 5.31 |
| CHEMBL130336 | — | IC50 | = | 5650.0 | nM | 5.25 |
| CHEMBL325757 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL264639 | — | IC50 | = | 7120.0 | nM | 5.15 |
| CHEMBL326205 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL323016 | — | IC50 | = | 9150.0 | nM | 5.04 |
| CHEMBL132790 | — | IC50 | = | 9470.0 | nM | 5.02 |
| CHEMBL131432 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL305535 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL106414 | — | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL323276 | — | IC50 | = | 60400.0 | nM | 4.22 |
| CHEMBL133842 | — | IC50 | = | 65400.0 | nM | 4.18 |
| CHEMBL323259 | — | IC50 | = | 70800.0 | nM | 4.15 |
| CHEMBL108267 | — | IC50 | = | 99000.0 | nM | 4.00 |
| CHEMBL133685 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL131699 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL133395 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL336737 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL110175 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL130041 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL110224 | — | IC50 | = | 258000.0 | nM | - |
| CHEMBL130984 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL428685 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL106554 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL131674 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL339176 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL130934 | — | IC50 | > | 100000.0 | nM | - |