Compound Detail
CHEMBL131432
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Basic Information
| ChEMBL ID | CHEMBL131432 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RJGMXYUXNYIXES-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
462.5
MW (Da)
5.57
ALogP
6
HBA
0
HBD
71.1
PSA (Ų)
0.34
QED
1
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase CHEMBL247 | IC50 | 5.0 | 5.0 | 10000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase | IC50 | = | 10000.0 | nM | 5.0 | Inhibitory activity against HIV-1 Reverse Transcriptase with rCdG as the templat... | 11708913 |
| Human immunodeficiency virus type 1 reverse transcriptase | IC50 | = | 10000.0 | nM | 5.0 | Inhibition of HIV-1 Reverse transcriptase using poly-(rc)-oligo(dg) as the templ... | 10579849 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11708913 | 10.1021/jm010212m | CEM-SS | 2 |
| 11708913 | 10.1021/jm010212m | Human immunodeficiency virus type 1 reverse transcriptase | 1 |
| 10579849 | 10.1021/jm990343b | Human immunodeficiency virus type 1 reverse transcriptase | 1 |
| 10579849 | 10.1021/jm990343b | CEM-SS | 1 |
| 10579849 | 10.1021/jm990343b | CCRF-CEM | 1 |
Data from ChEMBL 36 via Core Engine