Assay Detail
Functional
CHEMBL802685
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for its activity at solubilized receptor (CHAPS/salt-solubilized preparation) from rat frontal cortex
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Frontal cortex |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
In vitro labeling of serotonin-S2 receptors: synthesis and binding characteristics of [3H]-7-aminoketanserin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.45 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18331 | PIRENPERONE | 2.0 | 1 | 8.15 |
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 8.11 |
| CHEMBL51 | KETANSERIN | 3.0 | 1 | 8.10 |
| CHEMBL1065 | METHYSERGIDE | 4.0 | 1 | 7.87 |
| CHEMBL267777 | RITANSERIN | 2.0 | 1 | 7.85 |
| CHEMBL440294 | PIPAMPERONE | 3.0 | 1 | 7.72 |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 7.57 |
| CHEMBL1255588 | — | — | 1 | 7.45 |
| CHEMBL219916 | DOMPERIDONE | 3.0 | 1 | 5.70 |
| CHEMBL25554 | — | — | 1 | 5.11 |
| CHEMBL416526 | BUFOTENINE | — | 1 | 4.90 |
| CHEMBL511 | PYRILAMINE | 4.0 | 1 | 4.70 |
| CHEMBL6066837 | (-)-BUTACLAMOL | — | 1 | 4.56 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 4.55 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18331 | PIRENPERONE | IC50 | = | 7.079 | nM | 8.15 |
| CHEMBL267930 | SPIPERONE | IC50 | = | 7.762 | nM | 8.11 |
| CHEMBL51 | KETANSERIN | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL1065 | METHYSERGIDE | IC50 | = | 13.49 | nM | 7.87 |
| CHEMBL267777 | RITANSERIN | IC50 | = | 14.13 | nM | 7.85 |
| CHEMBL440294 | PIPAMPERONE | IC50 | = | 19.05 | nM | 7.72 |
| CHEMBL6437 | MIANSERIN | IC50 | = | 26.92 | nM | 7.57 |
| CHEMBL1255588 | — | IC50 | = | 35.48 | nM | 7.45 |
| CHEMBL219916 | DOMPERIDONE | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL25554 | — | IC50 | = | 7762.47 | nM | 5.11 |
| CHEMBL416526 | BUFOTENINE | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL511 | PYRILAMINE | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL6066837 | (-)-BUTACLAMOL | IC50 | = | 27542.29 | nM | 4.56 |
| CHEMBL39 | SEROTONIN | IC50 | = | 28183.83 | nM | 4.55 |
| CHEMBL2 | PRAZOSIN | IC50 | = | 39810.72 | nM | 4.40 |