Assay Detail
Functional
CHEMBL802686
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Compound was evaluated for its activity at membrane-bound receptor (M+L+P fraction) from rat frontal cortex
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Frontal cortex |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
In vitro labeling of serotonin-S2 receptors: synthesis and binding characteristics of [3H]-7-aminoketanserin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.55 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18331 | PIRENPERONE | 2.0 | 1 | 9.33 |
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 9.21 |
| CHEMBL51 | KETANSERIN | 3.0 | 1 | 9.17 |
| CHEMBL267777 | RITANSERIN | 2.0 | 1 | 9.05 |
| CHEMBL440294 | PIPAMPERONE | 3.0 | 1 | 8.86 |
| CHEMBL1065 | METHYSERGIDE | 4.0 | 1 | 8.72 |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 8.52 |
| CHEMBL1255588 | — | — | 1 | 8.47 |
| CHEMBL219916 | DOMPERIDONE | 3.0 | 1 | 6.82 |
| CHEMBL416526 | BUFOTENINE | — | 1 | 6.47 |
| CHEMBL25554 | — | — | 1 | 6.16 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 6.04 |
| CHEMBL511 | PYRILAMINE | 4.0 | 1 | 5.99 |
| CHEMBL6066837 | (-)-BUTACLAMOL | — | 1 | 5.49 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18331 | PIRENPERONE | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL267930 | SPIPERONE | Ki | = | 0.62 | nM | 9.21 |
| CHEMBL51 | KETANSERIN | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL267777 | RITANSERIN | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL440294 | PIPAMPERONE | Ki | = | 1.39 | nM | 8.86 |
| CHEMBL1065 | METHYSERGIDE | Ki | = | 1.92 | nM | 8.72 |
| CHEMBL6437 | MIANSERIN | Ki | = | 3.04 | nM | 8.52 |
| CHEMBL1255588 | — | Ki | = | 3.41 | nM | 8.47 |
| CHEMBL219916 | DOMPERIDONE | Ki | = | 152.0 | nM | 6.82 |
| CHEMBL416526 | BUFOTENINE | Ki | = | 341.0 | nM | 6.47 |
| CHEMBL25554 | — | Ki | = | 697.0 | nM | 6.16 |
| CHEMBL39 | SEROTONIN | Ki | = | 919.0 | nM | 6.04 |
| CHEMBL511 | PYRILAMINE | Ki | = | 1032.0 | nM | 5.99 |
| CHEMBL6066837 | (-)-BUTACLAMOL | Ki | = | 3261.0 | nM | 5.49 |
| CHEMBL2 | PRAZOSIN | Ki | = | 11572.0 | nM | 4.94 |