Assay Detail
Functional
CHEMBL802687
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Compound was evaluated for its activity at solubilized receptor (CHAPS/salt-solubilized preparation) from rat frontal cortex
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Frontal cortex |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
In vitro labeling of serotonin-S2 receptors: synthesis and binding characteristics of [3H]-7-aminoketanserin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.75 | 8.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18331 | PIRENPERONE | 2.0 | 1 | 8.45 |
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 8.41 |
| CHEMBL51 | KETANSERIN | 3.0 | 1 | 8.40 |
| CHEMBL1065 | METHYSERGIDE | 4.0 | 1 | 8.17 |
| CHEMBL267777 | RITANSERIN | 2.0 | 1 | 8.15 |
| CHEMBL440294 | PIPAMPERONE | 3.0 | 1 | 8.02 |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 7.87 |
| CHEMBL1255588 | — | — | 1 | 7.75 |
| CHEMBL219916 | DOMPERIDONE | 3.0 | 1 | 6.00 |
| CHEMBL25554 | — | — | 1 | 5.41 |
| CHEMBL416526 | BUFOTENINE | — | 1 | 5.20 |
| CHEMBL511 | PYRILAMINE | 4.0 | 1 | 5.00 |
| CHEMBL6066837 | (-)-BUTACLAMOL | — | 1 | 4.86 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 4.85 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18331 | PIRENPERONE | Ki | = | 3.54 | nM | 8.45 |
| CHEMBL267930 | SPIPERONE | Ki | = | 3.88 | nM | 8.41 |
| CHEMBL51 | KETANSERIN | Ki | = | 3.97 | nM | 8.40 |
| CHEMBL1065 | METHYSERGIDE | Ki | = | 6.74 | nM | 8.17 |
| CHEMBL267777 | RITANSERIN | Ki | = | 7.06 | nM | 8.15 |
| CHEMBL440294 | PIPAMPERONE | Ki | = | 9.53 | nM | 8.02 |
| CHEMBL6437 | MIANSERIN | Ki | = | 13.46 | nM | 7.87 |
| CHEMBL1255588 | — | Ki | = | 17.74 | nM | 7.75 |
| CHEMBL219916 | DOMPERIDONE | Ki | = | 998.0 | nM | 6.00 |
| CHEMBL25554 | — | Ki | = | 3881.0 | nM | 5.41 |
| CHEMBL416526 | BUFOTENINE | Ki | = | 6295.0 | nM | 5.20 |
| CHEMBL511 | PYRILAMINE | Ki | = | 9976.0 | nM | 5.00 |
| CHEMBL6066837 | (-)-BUTACLAMOL | Ki | = | 13771.0 | nM | 4.86 |
| CHEMBL39 | SEROTONIN | Ki | = | 14092.0 | nM | 4.85 |
| CHEMBL2 | PRAZOSIN | Ki | = | 19905.0 | nM | 4.70 |