Assay Detail
Functional
CHEMBL802697
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimuscarinic potency is measured as its ability to block ACh-induced contractions of the rat ileum.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Molecular modification of anticholinergics as probes for muscarinic receptors. 3. Conformationally restricted analogues of benactyzine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.18 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70352 | BENACTYZINE | 2.0 | 1 | 7.46 |
| CHEMBL98190 | — | — | 1 | 6.35 |
| CHEMBL94568 | — | — | 1 | 6.19 |
| CHEMBL97775 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70352 | BENACTYZINE | Kd | = | 34.67 | nM | 7.46 |
| CHEMBL98190 | — | Kd | = | 446.68 | nM | 6.35 |
| CHEMBL94568 | — | Kd | = | 645.65 | nM | 6.19 |
| CHEMBL97775 | — | Kd | = | 19952.62 | nM | 4.70 |